Melatonin Zn-Se Pierpaoli


Created based on 40 years of research and experiments published in the most prestigious international scientific journals, Pierpaoli® Melatonin Zinc-Selenium helps to re-activates and restores the nocturnal phisiological melatonin peak products by the youthful pineal gland


In the medical protocol developed by me, Pierpaoli® Melatonin Zinc-Selenium could be helpful as a regulator and synchronizer of the body's internal biological clock which favors the functional preservation and protection of the pineal gland, helping to restore and re-synchronize the entire system of biological and hormonal cycles and, therefore, support the recovery and conservation of the body's youthful conditions.


Functions of melatonin and the pineal gland according to my research and studies





•Rebalances hormonal, metabolic and immune functions

•Protects the Pineal gland, maintaining its functions

•maintains youthful metabolic conditions

•Synchronizes physiological cycles of the body

•Helps in situations of fatigue and stress

•Helps in deficient physiological conditions

•Helps in resolving sleep-wake rhythms

•Helps with jet-lag

Forty years of studies have demonstrated that the re-synchronization of hormone (neuroendocrine) cycles by the pineal gland - and its preservation and protection by administering a correct formulation of melatonin at night starting at a young age (from 30 to 35 years) - helps keep you in youthful conditions

Hormones and all molecules in the body closely follow a day-night (circadian rhythms), sun-moon and seasons cycle (especially light and temperature). These cycles are the foundation of health. Aging is also due to the break in the synchronized relationship between circadian/seasonal and hormonal rhythms. This relationship is regulated by the structures of the nervous system forming the hypothalamic-pituitary-pineal brain circuit, which integrates and synchronizes the night-day cycles of the synthesis and secretion of all hormones. Aging in humans is, therefore, certainly linked to a genetic program, but the expression of this program is precisely the circadian periodicity of the hormone system. 

In turn, day and night hormonal cycles and rhythms are closely controlled by the stimuli of the pineal gland, which integrates and sends back messages to the endocrine glands.


The pineal gland (or epiphysis), which regulates the synthesis and cyclical secretion of hormones in our body, Melatonin Plasma Levels Decline Rapidly with Ageproduces melatonin. As it ages, it produces increasingly less melatonin. 

During childhood, melatonin production reaches its maximum peak. It then begins to decline slowly: at about 45, there is a further drop and at around 80 the level of melatonin in the body of an otherwise healthy individual is less than half that of a young individual.



Levelling until the complete disappearance of the nocturnal melatonin peak, in addition to the constant reduction of zinc levels with aging, are tell-tale signals of the body's aging and of the decline of hormonal control over our essential functions, including sleep, strength, adaptation to temperatures, sexual vigor, resistance to infections and so forth.

It is, therefore, a matter of preventing this trend by administering a correct amount of melatonin to maintain a constant nocturnal peak typical of youth. By doing so, you are helping the pineal gland and, therefore, the entire body to recover that youthful condition that is essential to preserve the biological rhythms that control hormones and immunity, as well as circadian synchronization (physiological cyclicity) of the entire hormonal system that closely Normal Melatonin Peaksregulates natural metabolic and immunological functions. This favors, accordingly, the normalization of all immunological, metabolic and endocrine functions.


Since the pineal gland produces melatonin only at night, by taking the correct amount of melatonin at night  (and obtaining the corresponding melatonin peak during the night), the pineal gland no longer needs to produce melatonin through a very complex synthesis process and "goes to rest”. This way, you can help to preserve and protect the functional integrity of the pineal gland and, therefore, restore all hormonal rhythms in addition to slowing down aging (which is certainly a clearly genetically programmed process in the brain, but which is expressed through hormonal regulation).

Nocturnal peak during youth

Nocturnal peakThe uniqueness of Pierpaoli Melatonin Zinc-Selenium lies in that it has been developed with intent to achieve a peak release of melatonin between 1 and 3 a.m. comparable to that produced in the same time slot by the pineal gland during youth. 

According to my research, by replicating the physiological nocturnal peak typical of youth, you are helping the pineal gland to regenerate and stay young and to produce molecules that regulate the entire hormonal system also called "neuroendocrine” system. It helps preserve the biological rhythms that control hormones and immunity, as well as circadian synchronization (physiological cyclicity) of the neuroendocrine system that regulates the body's natural metabolic and immunological functions. Result: it favors the normalization of all endocrine, immunological, and metabolic functions.

Why zinc and selenium?

Zinc and selenium are two molecules that cooperate and synergize with melatonin to regulate and resynchronize hormonal, metabolic and immune functions which are altered during aging. For instance, a number of studies and experiments have shown that zinc can help to redress immunodepression generated by aging and other hormonal and metabolic alterations typical of old age. Furthermore, with age, zinc is not absorbed enough through the bowels and is a certain indicator of aging (elderly people have very low zinc levels) and must, therefore, be supplemented to prevent alteration of immunity.

For this reason, in Pierpaoli Melatonin, the three fundamental anti-aging molecules (melatonin, zinc and selenium) are combined in a single synergistic blend, which is designed to achieve the maximum beneficial effect in the metabolic and immunobiological system of people who take it.


To assess the beneficial effects of Pierpaoli® Melatonin Zinc-Selenium, all you need is a normal blood test before you start taking it and then check again after 6 months or a year (in the absence of diseases, we recommend that you always measure FT3, FT4, TSH, prolactin and testosterone).

Why is 1 milligram enough?

Melatonin does not have a quantitative pharmacological value, as has been demonstrated in hundreds of scientific journals, but is only necessary to “rest” the pineal gland. The “physiological” (dose-dependent) effect of taking Melatonin is obtained within the range of physiological values of the endogenous plasma melatonin (50-200 pg / ml) with equal doses, in a young healthy adult, at 0.1-0.3 mg. It has been proven that doses of 0.3 - 0.5 mg are already effective and are able to perfectly imitate a youthful nocturnal peak. Administering 0.3 mg doses of Melatonin to adult males will result in blood levels close to physiological levels. A 0.3 mg dose of Melatonin is in fact sufficient to increase the level of Melatonin in blood about 120 picograms per milliliter, a level that corresponds to the nocturnal peak of melatonin in youth.


It should, however, be considered that individual needs may vary according to differences in metabolism. Precisely because everybody has a different intestinal absorption, I prudentially suggest taking 1 to 3 mg. There is no risk of overdose. Melatonin is water-soluble, and the excess quantity is eliminated by kidneys in the urine. During a clinical study, a daily dose of 6 grams (or 6,000 times higher than recommended) was given to some women for a long period of time without the appearance of any side effects.


In fact, as we have said, a dose of 0.3 - 1.0 mg Melatonin Zinc-Selenium tablets is normally sufficient to return the nocturnal peak of melatonin to youthful levels and to saturate the organism during the night.


Diagrams from: 




1. JELLIN JM ET AL., EDS. Pharmacist’s letter/prescriber’s letter natural medici- nes comprehensive database.
2. HARTTER S ET AL. Increased bioavailability of oral melatonin after fluvoxami- ne coadministration. Clin Pharmacol Ther. 2000; 67:1-6.
3. VON BAHR C ET AL. Fluvoxamine but not citalopram increases serum me- latonin in healthy subjects -- an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin. Eur J Clin Pharmacol. 2000; 56:123-7.
4. LUSARDI P ET AL. Cardiovascular effects of melatonin in hypertensive pa- tients well controlled by nifedipine: a 24-hour study. Br J Clin Pharmacol. 2000; 49:423-7.
5. PIERPAOLI, W. AND REGELSON W. WITH CAROL COLMAN, “The Mela- tonin Miracle”, Simon & Schuster, New York, 1995.
6. PIERPAOLI, W. The pineal gland: a circadian or a seasonal aging clock? Aging 3: 99-101, 1991.
7. PIERPAOLI, W. DALL’ARA, A, PEDRINIS, E. AND REGELSON, W. The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice.
8. Second Stromboli Conference on Aging and Cancer, June 1990. Ann. N.Y. Acad. Sci. 621: 291-313, 1991.
9. PIERPAOLI, W., AND LESNIKOV, V.A. The pineal aging clock. Evidence, mo- dels, mechanisms, interventions. The Aging Clock. Third Stromboli Conference on Agingand Cancer, June 1993. Ann. N.Y. Acad. Sci. 719: 461-473, 1994.
10. PIERPAOLI, W. AND REGELSON, W. Pineal control of aging: effect of mela- tonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA, 94: 787-791, 1994.
11. MOCCHEGIANI, E., BULIAN, D., SANTARELLI, L., TIBALDI, A., MUZZIOLI, M., PIERPAOLI, W. AND FABRIS, N. The immuno-reconstituting effect of melato- nin or pineal grafting and its relation to zinc pool in aging mice. J. Neuroimmunol. 53: 189-201, 1994.
Melatonina Zinco-Selenio Dr.Pierpaoli
12. MOCCHEGIANI, E., BULIAN, D., SANTARELLI, L., TIBALDI, A., MUZZIOLI, M., LESNIKOV, V., PIERPAOLI, W. AND FABRIS, N. The zinc pool is involved in the immunoreconstituting effect of melatonin in pinealectomized mice. J. Phar- mac. & Exp. Therap. 277: 1200-1208, 1996.
13. MOCCHEGIANI, E., BULIAN, D., SANTARELLI, L., TIBALDI, A., PIERPAOLI, W. AND FABRIS, N. The zinc-melatonin interrelationship. A working hypothesis. The Aging Clock.
14. Third Stromboli Conference on Aging and Cancer, June 1993. Ann. N.Y. Acad. Sci. 719: 298-307. 1994.
15. FABRIS, N. Neuroendocrine-immune aging: an integrative view on the role of zinc. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993.
16. ANN. N.Y. Acad. Sci. 719: 353-368, 1994. 17. MEISTER, A. AND ANDERSON, M.E. Glutathione. Ann. Rev. Biochem. 52:
711-760, 1983. 18. PIERPAOLI, W. AND LESNIKOV, V.A. Theoretical considerations on the na-
ture of the pineal “aging clock”. Gerontology 43: 20-25, 1997.
Effects of melatonin in perimenopausal and menopausal women. A randomized and placebo controlled study. Exp. Gerontol. 36, 297-310, 2001.




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