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ProVision Pierpaoli

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ProVision® is an innovative formulation created by me, a precious supplement to preserve eyesight


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General indications 

  • Beneficial for a healthy eyesight;
  • Contributes to preserving eyesight;
  • Contributes to protecting against oxidative stress;
  • Helps to supplement the nutritional needs of the visual apparatus (retina, macula and crystalline); 
  • Helps to keep the visual apparatus in good conditions;
  • Improves issues linked to visual fatigue.
  • Moreover, ProVision® provides precious help to all people experiencing age-related macular degeneration.

For almost 50 years, I have been studying pathologies of the retina and damage caused by excessive direct light on the respiratory function of the retina and have published papers recognized at an international level, since 1961.

ProVision® has been formulated to cover metabolic and oxidative needs of the eyes in general and of the retina in particular and has been developed based on a clinical trial.

 


The extensive use of computers, television, videogames and permanent artificial lights for hours every day, along with low humidity at home and in office, greatly stress and strain our eyes. In particular they “wear out” and “use up” the visual cells of the retina, which are “thirsty” for oxygen and minerals. Additionally, when they are stressed by an intense and variable light of changing wavelength (for example in discotheques), they tend to degenerate.

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ProVision and macular degeneration of the retina

Age-related macular degeneration of the retina (AMD) is a pathology that affects the macula (the centermost part of the retina). Today, it is considered to be the main cause of the loss of central vision (blindness) and, in industrialized countries, it is one of the leading causes of loss of visual acuity in subjects over 50 .

The dry form is the more widespread (85% of patients) than the wet form (15%). Those affected present decreased vision in the central area of the visual field and/or a deformation of images. AMD progresses gradually and can lead to complete and irreversible loss of central vision (complete blindness is nonetheless rare).

 

 

The benefits of integration with ProVision® according the study

- Contributes to the control of eye pigmentation by regulating the light that reaches the photoreceptors 

- Contributes to the elimination of toxic hydroxy-radicals

- Contributes to the protection of the retinal epithelium against oxidative damage 

- Restores circadian rhythms 

- Helps rebalance the neuroendocrine system

- Has excellent tolerance and easy oral administration 


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Dose: A tablet half an hour before going to bed, preferably between 10:00 pm - 12:00 am.

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REFERENCES

  1. Hussein G et al. Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod. 2006 Mar;69(3):443-9. Review. 
  2. Stahl W. Macular carotenoids: lutein and zeaxanthin. Dev Ophthalmol. 2005;38:70-88. Review. 
  3. Dwyer JH, Paul-Labrador MJ, Fan J, Shircore AM, Merz CN, Dwyer KM. Progression of carotid intima-media thickness and plasma antioxidants: the Los Angeles Atherosclerosis Study. Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):313-9. 
  4. Ribaya-Mercado JD, Blumberg JB. Lutein and zeaxanthin and their potential roles in disease prevention. J Am Coll Nutr. 2004 Dec;23(6 Suppl):567S-587S. Review. 
  5. Richer S, Stiles W, Statkute L, Pulido J, Frankowski J, Rudy D, Pei K, Tsipursky M, Nyland J . Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr;75(4):216-30. 
  6. PANG, S.F. & D.T. YEW. 1979. Pigment aggregation by melatonin in the retinal pigment epithelium and choroid of guinea pigs cavia porcellus. Experientia 35: 213 – 233.
  7. Hartmann D, Thurmann PA, Spitzer V, Schalch W, Manner B, Cohn W. Plasma kinetics of zeaxanthin and 3'-dehydro-lutein after multiple oral doses of synthetic zeaxanthin. Am J Clin Nutr. 2004 Mar;79(3):410-7. 
  8. LIANG, F.Q., L. GREEN, C. WANG, et al. 2004. Melatonin protects human retinal pigment epithelial (RPE) cells against oxidative stress. Exp. Eye Res. 78: 1069 – 1075.  
  9. Stringham JM, Hammond BR Jr. Dietary lutein and zeaxanthin: possible effects on visual function. Nutr Rev. 2005 Feb;63(2):59-64. Review. 
  10. TOUITOU, Y., P. LE HOANG, B. CLAUSTRAT, et al. 1986. Decreased nocturnal plasma melatonin peak in patients with a functional alteration of the retina in relation with uveitis. 70: 170 – 174. 
  11. PIERPAOLI, W., A. DALL’ARA & E. PEDRINIS. 1991.  The pineal control of aging: the effects of melatonin and pineal grafting on the survival of old mice. Ann. N.Y. Acad. Sci. 620: 291 – 313. 
  12. SCHER, J., E.WANKIEWICZ, G.M.BROWN, et al. 2003. AII amacrine cells express the MT1 melatonin receptor in human and macaque retina. Exp. Eye Res. 77: 375 – 382. 
  13. WIECHMANN, A.F. & C.R. WIRSIG- WIECHMANN. 1994. Melatonin receptor distribution in the brain and retina of a lizard, Anolis carolinensis. Brain Behav. Evol. 43: 26 – 33. 
  14. REDBURN, D.A. & C.K. MITCHELL. 1989. Darkness stimulates rapid synthesis and release of melatonin in rat retina. Visual Neurosci. 3: 391 – 403. 
  15. CAHILL, G.M. & J.C. BESHARSE. 1992. Light- sensitive melatonin synthesis by Xenopus photoreceptors after destruction of the inner retina. Visual Neurosci. 8: 487 – 490. 
  16. BANAS, I., B. BUNTNER & T. NIEBROJ. 1995. Levels of melatonin in the serum of patients with retinitis pigmentosa. Klin. Oczna 97: 321 – 323.   
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Disclaimer: The information presented herein strictly reflects the opinion of Prof. Walter Pierpaoli and is intended to provide information and for educational purposes. The information herein intends to support, and not replace, the existing relationship between a patient/visitor of this website and his/her referring physician and, in no case, can it be considered a diagnosis or used as an alternative to a medical examination. Prof. Pierpaoli undertakes no responsibility for any health consequences of any person who reads and follows the information contained on this site. All readers of the contents on this website, especially those who take prescription or over-the-counter drugs, should consult their physicians before beginning any nutritional or supplemental program or prior to making lifestyle changes. The contents herein are in compliance with the guidelines relevant to the application of arts. 55, 56 and 57 of the new Code of Medical Ethics and are intended for the general public.