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The Miracle Molecule

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WHAT IS MELATONIN?
In our bodies, melatonin is the molecule naturally produced within the pineal gland, the glandular organ nestled between the cerebral hemispheres that the great French philosopher Descartes once proposed to be the "seat of the soul." We find melatonin everywhere in the biological world, from unicellular organisms to the vertebrates.  Melatonin is the "Master Hormone-Modulating Molecule" but it is misleadingly called itself "hormone". It is  the body's regulator of all hormones, the molecule which controls the production of almost every other human hormone.  Melatonin also helps regulate our "sleep/wake", or circadian cycles.  Melatonin production reaches its peak in puberty and then continues to decrease as we grow older, resulting in the physically degenerative condition commonly referred to as "aging".  As we "age", our bodies become vulnerable to a  host of illnesses and diseases, including insomnia, immune dysfunctions, heart disease and cancer. But research shows that taking small doses of synthetic melatonin supplements at the time of life when naturally produced melatonin levels decline can halt and even reverse the negative effects of aging.

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SELENIUM.

This essential trace mineral has powerful antioxidant properties with anti-aging properties. It is an essential building block for the making of glutathione peroxidase, one of our most important enzymes that neutralizes free radicals.

It is a fact that as you age, your levels of selenium falls. Selenium blood levels drop 7 % after age 60 and 24 % after age 75. Worse yet, declining levels of selenium signifies less antioxidant activity in our body. People with decreased levels of selenium are associated with higher incidence of heart disease, cancer, and arthritis. Additionally, Animal studies show that selenium block up to 100 % of various tumors types of tumors. A University Arizona study of 1,700 elderly Americans show that those with low level of selenium are more apt to have polyps in the GI tract (33 % compared to 9 % in those with high level of selenium). In another study of 3,000 older persons on selenium, this time in a Dutch study, showed a reduction in the risks for lung cancer by 50 %. Likewise, selenium intake can lead to reduced heart disease. It prevents platelet aggregation that normally leads to blood clots and it blocks oxidation of bad type of LDL cholesterol.
A large-scale Finnish study showed that those with lowest level of selenium in their blood were 3 times more apt to die of heart disease.Selenium can be found in grains, sunflower seeds, meat, seafood especially tuna, swordfish, and garlic. The anti-aging nut, the Brazil nut, contains about 100 mcg of selenium due to the soil.

One should take between 75-200 mcg of selenium per day for anti-aging purposes. Most common multivitamins do not contain that much selenium and therefore most likely you will need a separate selenium capsule as supplement.


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MELATONIN AND SLEEP
Sleep is crucial to our health and well-being; we need it as much as we need oxygen.It allows our bodies to rest and refuel and gives the body's cells a chance to repair and regenerate.The average adult needs between 8 and 9 hours of sleep per night to allow for the completion of this regeneration process.But most adults get less than 7!  And study upon study continues to show that people who don't get adequate sleep are at increased risk for a myriad of health problems and illnesses including obesity, diabetes, immune-system dysfunction, as well as impaired job performance, concentration and productivity in many other activities.The sleep cycle stems form an interaction between how much sleep you get (hours) and the CIRCADIAN CYCLE -the 24 hour sleep/wake cycle of light and darkness created by the rotation of the earth.  The PINEAL GLAND, a pea-sized structure at the center of the brain, works with the hypothalamus gland to control your sleep/wake cycles.At night, in darkness, the pineal gland produces MELATONIN, which causes your heart rate to slow down, your body temperature to drop - physiological conditions that allow for deep, restful sleep.
As we age, the amount of melatonin produced by our body lessens, resulting in the sleep disturbances.Numerous scientific studies have shown that taking synthetic melatonin as a supplement can help correct the irregularities in the body's circadian cycle that prevent a good night's sleep.  Melatonin supplements have worked wonders in the treatment of insomnia, sleep disturbances, jet lag and seasonal affective disorder.But sleep isn't melatonin's only story.  In extensive clinical trials*, internationally renowned researcher and medical doctor Walter Pierpaoli, discovered that the benefits of taking synthetic melatonin supplements reach far beyond a good night's sleep.  So far, in fact, you might call it "The Miracle Molecule".

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MELATONIN AND THE AGING CLOCK
In his now-famous groundbreaking scientific study, "The Aging Clock: The Pineal Gland and Other Pacemakers in the Progression of Ageing and Carcinogenesis", Dr. Pierpaoli proved* that conventional wisdom regarding how we age is flawed.  Aging is not the inevitable result of passing years; it is actually a degenerative physical condition that can be slowed down, stopped and even reversed by simply re-setting your "aging-clock".Through exhaustive research*, Dr. Pierpaoli discovered that the pineal gland, in its role as the producer/keeper of melatonin, functions as the body's "aging clock".  A young pineal gland, through its Master Molecule, melatonin, sends a message of "youth" throughout the body, keeping the body healthy and strong.As the pineal gland ages, however, the message it sends to the body is "slow down, you're old" and subsequently, the body systems comply, following closely the "master", growing older and older until we eventually die.This  aging-preventing and aging-promoting role of the pineal gland has been most dramatically  demonstrated by  transplanting the pineal gland from young into old animals and from old animals into young animals.The story of the discovery has also been illustrated in the popular book "The Melatonin Miracle", Simon & Schuster, New York, 1995.  In addition,  extensive clinical trials* showed that melatonin supplements in aging subjects restored pineal glands to their youthful, productive states, restored balance to the body and literally reversed the aging process.
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MELATONIN AND STRESS
It's the 21st century - stress is part of our daily lives. We are subjected to it constantly, in many cases plagued by it.  But what exactly is stress?  The body's stress response can be likened to an airplane getting ready for take-off. Virtually all body systems (e.g., the heart and blood vessels, the immune system, the lungs, the digestive system, the sensory organs, and brain) are modified to ready us to "fight or flee" - a physiological response mechanism left over from prehistoric times, when we literally had to fight or flee to survive.  In the brain, the HPA hypothalamic-pituitary-adrenal (HPA) system is activated, triggering the production and release of CORTICOSTEROIDS, including the primary stress hormone CORTISOL. Corticosteroids are involved in a wide range of physiological systems including: stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels and behavior.  Numerous scientific studies have proven that SLEEP DEPRIVATION leads to an abnormal elevation in corticosteroids. .  Prolonged exposure to elevated levels of corticosteroids can:
- raise blood sugar levels, increasing the risk of diabetes and obesity;
- damage the heart;   
- weaken the bones, leaving the vulnerable to breaks and fractures;   
- damage the brain and affect our ability to think clearly and retain information in memory;  
 - suppress and damage the immune system by  decreasing the number of active white blood cells  in our bodies.
Clinical trials* show that melatonin supplementation normalizes corticosteroid levels in our bodies. But taking melatonin doesn't just protect us against the negative effects of stress by keeping corticosteroid levels in check.  Melatonin actually works with ENDORPHINS, special stress-reducing, pain relieving chemicals produced by the immune system.  Melatonin enhances the effect of endorphins, thereby aiding the body to withstand stress and promote a greater sense of general well-being.
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MELATONIN AND YOUR IMMUNE SYSTEM.
The immune system is, quite possibly, the most intricate and dynamic system in the human body.  It is designed to respond to protect you against the millions of external, unwanted bacteria, microbes, parasites and viruses that can attack and destroy your body. T-cells (thymus cells, white blood cells that attack virus-infected cells, foreign cells and cancer cells) play a pivotal role in immune response. T-cells also produce a number of substances that regulate the immune response.  A multitude of healthy, active T-cells are necessary for our healthy survival.  As we age, the thymus gland, the gland that stores and controls T-Cells, deteriorates, causing the T-cells to become less effective.Our immune system gradually breaks down, leaving us vulnerable to the onset of disease.Clinical trials* show that melatonin supplementation increases the weight of the thymus, as well as the activity of the T-cells.  Clinical trials* also show that melatonin works to strengthen the body's antibody response, helps fight against viruses and improves thyroid function - all of which boost and support the immune system.
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MELATONIN AS CANCER PREVENTION AND TREATMENT
Improving T-cell function doesn't just bolster your immune system.T-cells are the body's primary cancer fighters.Cancer is a group of disease in which the body's cells are abnormal and divide without control. Cancer cells may invade nearby tissues and/or spread through the bloodstream and lymphatic system to other parts of the body.   There is strong evidence that in its role as the "MASTER REGULATORY MOLECULE", i.e., the regulator of other hormones, melatonin may help prevent hormone-dependent cancers (including breast cancer and prostate cancer). Melatonin is also a strong tool in the prevention of cancer in its role of strengthening the immune system (the body's ability to identify and destroy abnormal cells that may turn cancerous). Melatonin prevents the age-related decline in your immune system that leaves your body vulnerable to cancer.  Clinical trials* have shown that melatonin can diminish the effects of hormones that trigger certain cancers, including breast cancer and prostate cancer. Melatonin also hinders spindle formation, which can potentially slow down cell division. If you already have cancer, supplementing melatonin before and after, but not during the course of your chemotherapy, could be a beneficial treatment support.  Clinical trials* have shown that melatonin supplements taken can protect bone marrow cells from the ravaging effects of chemotherapy.  But ask your doctor.
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MELATONIN'S OTHER MIRACLES
Dr. Pierpaoli's research and research of many other scientists also showed that melatonin can:
HELP MAINTIN A HEALTHY HEART BY:
Stabilizing cholesterol and other essential blood lipids.  Clinical trials* indicated that melatonin can reduce the effect of cholesterol intake on blood levels of cholesterol.
Protecting against high blood pressure.  By slowing down the "aging clock", melatonin can help stay the tendency for blood pressure levels to rise as we age.  In addition, melatonin's role as a "sleep aid" can help keep the body in the restful restorative sleep state that allows blood pressure levels to drop.
Counteracting the harmful effects of stress.  Melatonin stabilized the production of CORTICOSTEROIDS, harmful stress hormones that have been proven to damage the heart
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HELP MAINTIN A HEALTHY SEX LIFE BY:
Restoring both male and female sex organs and drive to their youthful "peak performance" levels.  Clinical trials* show melatonin can prevent age-related deterioration of sexual organs, which has been linked to impotency, sexual dysfunction and lack of desire.

Restoring libido-enhancing sex hormones to their youthful "peak performance" levels as the body's "master molecule".

Promoting and supporting prostate health. Clinical trials* show melatonin to be an inhibitor of the 5-alpha-reductase enzyme, which can stimulate the growth of prostate cells (resulting in an enlarged prostate).  Melatonin also has been shown to restore and maintain normal zinc levels, essential to maintaining a healthy prostate.

Preventing ARTERIOSCLEROSIS, in which the arteries or the heart become clogged with plaque.  Through its role in normalizing cholesterol levels, melatonin may also protect against this age-related disease, which is one of the leading causes of male impotency.

Stabilizing and synchronizing couples' sleep/wake cycles.

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And although further research must be done before we can be sure, melatonin shows to hold great promise in the treatment and prevention of dozen of other conditions, diseases and illnesses including asthma, diabetes, menopause, Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Down Syndrome and AIDS.
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WHY  Melatonin Zn-Se of Dr. Pierpaoli?
Melatonin Zn-Se of Dr. Pierpaoli contains the purest, most effective form of synthetic melatonin available; each tablet has been scientifically tested for biological activity and chemical purity.  Synthetic melatonin is produced  by synthesis from pharmaceutical grade ingredients, starting from serotonin extracted from coffee beans,  and is molecularly identical to the melatonin produced in the human body. NEVER, EVER use "bovine", "animal" or "natural" grade melatonin.  These grades of melatonin contain the actual extracts of the pineal gland and derive from animal tissue, which means it could contain viruses or proteins that could cause an undesired antibody response.  Dr. Pierpaoli and his colleagues have investigated the possible mechanisms and also the molecules which presumably cooperate and synergize  with melatonin  in the regulation and re-synchronization of fundamental immunological and hormonal functions which are lost or deranged in the course of aging. During  recent studies and long-term experiments with old rodents, it has been observed  that zinc can correct completely aging-dependent immunodepression and several other  hormonal and metabolic alterations typical of aging.  It has been found  that  the low zinc levels in aging animals can be restored  to normal values with nocturnal administration of melatonin or transplantation of the pineal gland from  young  into older animals6-9. Zinc is an essential component of more than 200 enzymes and  one of the most relevant trace elements in the body8,9.It is thus clear that additional  zinc  must be supplemented daily to the body of an aging organism with a low zinc balance, in order that melatonin can better exert its anti-aging activities on the entire hormonal and immune systems! This important  and novel scientific observation of the powerful anti-aging and immonoenhancing activity of the combination of zinc and melatonin has now resulted into the development of Zn-Se Melatonin of Dr. Pierpaoli! Also selenium is a fundamental trace element of the body and possesses powerful anti-cancer effects. Modern agriculture and alimentary habits have dramatically decreased the daily input of selenium from the diet. Selenium is essential  for the enzymatic reaction responsible for the synthesis of glutathione, a powerful physiological molecule which constantly protects the body from oxidative damage. A lack of selenium will thus result into a loss of the detoxification capacity of the body, immunodepression and onset of  degenerative diseases and cancer10. This is the reason why Melatonin Zn-Se of Dr. Pierpaoli combines, in a unique synergistic combination, three fundamental anti-aging molecules, where melatonin plays the master role for reactivation and restoration of its natural night peak to juvenile levels, this resulting into normalization of all measurable immunological and endocrine functions in the course of aging. The positive aging-postponing, metabolic and immunological effects of  Melatonin Zn-Se od Dr. Pierpaoli can be easily measured by anybody  by means of a normal periodic check-up!Although synthetic melatonin is one of the least toxic substances in existence and produces almost no side effects, it does produce somnolence (sleepiness) in most of the population at higher dose.  Melatonin should not be taken with MAOI drugs, as MAOI's inhibit the breakdown of melatonin in the body.  Melatonin should not be taken during pregnancy or while nursing.  Melatonin should not be taken with alcohol, NSAIDS (anti-inflammatory medications) or beta-blockers.  CONSULT YOUR DOCTOR PRIOR TO BEGINNING A SYNTHETIC MELATONIN REGIMEN.


*Dr. Pierpaoli's groundbreaking research on the pineal gland and melatonin was presented at the Third Stromboli Conference on Aging and Cancer and published in 1994 by the Annals of the New York Academy of Sciences under the title: "THE AGING CLOCK: The Pineal Gland and Other Pacemakers in the Progression of Aging and Carcinogenesis" and in the Proceedings of the National Academy of Sciences, 1994.   In 1995, "THE MELATONIN MIRACLE", co-authored by Dr. Pierpaoli and Dr. William Regelson (with Carol Coleman) and based on Dr. Pierpaoli's research, was published by POCKET BOOK, a division of Simon and Schuster.  All clinical trials in Dr, Pierpaoli's study were conducted on laboratory mice and all claims made in the study were based on those trials.  Scientists choose mice for medical research because the manner in which illnesses present in mouse bodies virtually duplicates the pathology of the same illnesses in human bodies.  In addition, mice are subject to the same biological rhythms as humans.  At  present, results of many clinical studies  with melatonin are being published in the scientific literature  supporting and fully confirming  the findings reported with mice and other rodents.



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Disclaimer: The information presented herein strictly reflects the opinion of Prof. Walter Pierpaoli and is intended to provide information and for educational purposes. The information herein intends to support, and not replace, the existing relationship between a patient/visitor of this website and his/her referring physician and, in no case, can it be considered a diagnosis or used as an alternative to a medical examination. Prof. Pierpaoli undertakes no responsibility for any health consequences of any person who reads and follows the information contained on this site. All readers of the contents on this website, especially those who take prescription or over-the-counter drugs, should consult their physicians before beginning any nutritional or supplemental program or prior to making lifestyle changes. The contents herein are in compliance with the guidelines relevant to the application of arts. 55, 56 and 57 of the new Code of Medical Ethics and are intended for the general public.